Paranormal investigators Ed and Lorraine Warren put Annabelle in their Artifacts room, hoping that this will seal the evil doll's powers in there. However, Annabelle manages to wreak havoc anyway by awakening the evil in the room and setting the Warrens' young daughter, Judy, as its new target. Judy, along with her teenage babysitter cousin and the cousin's friend, will have to go up against the evil doll.